雅克宜®
水性丙烯酸树脂肠溶包衣系统
雅克宜® 水性丙烯酸树脂肠溶包衣系统是优化的“一步”全色系水性丙烯酸类系统，具备 pH 靶向释放功能。 该系列产品适用于片剂或多颗粒口服固体制剂，尤其适合质子泵抑制剂（PPI）等应用。
Ensuring the Best Match for Your Application
Acryl-EZE®, aqueous acrylic enteric systems are a range of fully formulated high-performance coatings that provide pH targeted resistance. The formulations are designed for use on tablets or multiparticulate solid oral dosage products, including proton pump inhibitor (PPI) applications.
Targeted pH Applications
Acryl-EZE is available for use with choice of plasticizer for application flexibility and customization, and protects against acidic conditions with fast release in buffer (small intestinal fluids) conditions.
Acryl-EZE II is an optimized high-performance coating that offers enteric protection in the intermediate pH range media, suitable for proton pump inhibitor (PPI) applications and provides enteric protection at lower weight gains compared to Acryl-EZE systems.
Performance Validated through In Vivo Studies
Acryl-EZE II formulations can provide enhanced enteric protection up to pH 5.0 through the addition of a specialized top-coat. In vitro drug assay performance
has been validated with a human volunteer study in the challenging fed state conditions demonstrating comparable bioavailability on omeprazole multiparticulates.
Time Savings in Development and Production
- Fully formulated, complete system
- Simple to dispense and disperse (20 minutes), with easy cleanup
- Reduced raw material inventory and QC requirements
- Application flexibility
Reliable and Reproducible Performance
- Simple coating procedure using conventional processes
- No curing step required, for most applications
Meeting Regulatory Requirements
The ingredients used in Acryl-EZE formulations meet the requirements for the key pharmaceutical markets around the world. Choose from a range of acceptable pigment options to meet your marketing needs.